Technologies & SolutionsA spray-type adhesion barrier
Easily sprayed to exactly where you need it.
A spray-type adhesion barrier with nozzle applicator
When tissue is lost or damaged during surgery, etc., a phenomenon known as postoperative adhesions may occur during the healing process. In this process, organs and tissue surfaces that are normally separated become connected.
Terumo has developed AdSpray, a spray-type adhesion barrier as an intervention to reduce postoperative adhesions.
This product forms a hydrogel which acts a physical barrier. Terumo has adopted NHS (N-hydroxysuccinimide)-modified carboxymethyl dextrin polymer. The powder containing this main ingredient forms an acidic solution. When mixed with an alkaline solution, a crosslinking reaction occurs that forms intramolecular ester bonds, and a gel is quickly formed.
Starting from this gel technology, Terumo moved ahead with in-house development, including the development of an applicator, and brought it to market under the concept of ‘an easy-to-use spray-type adhesion barrier.’
Since the product’s launch, it has been used in a variety of abdominopelvic surgeries, as well as in various approaches such as open surgery, laparoscopic surgery, and robot-assisted surgery, in order to reduce the frequency, extent, and severity of postoperative adhesions.
Four features incorporated during the development of AdSpray
POINT01
Excellent biocompatibility
Many adhesion barriers are made from bioabsorbable materials and are designed to be absorbed by the body after the period of isolation between injured tissues. AdSpray uses dextrin compounded from a substance derived from corn starch.
POINT02
Hydrogel that can be applied to complex surgical sites
Two solutions pushed out of the spray applicator are mixed uniformly by gas in the applicator tip, and sprayed in a mist around the surgical site. The two sprayed solutions quickly form a gel over the damaged area and form a barrier, making it effective even when sprayed along unevenly shaped areas.
POINT03
Excellent accessibility suitable for laparoscopic surgery
AdSpray’s nozzle can be inserted through a 5mm port, making it possible to approach the target surgical field in various abdominopelvic surgeries. It can be used regardless of surgical approach, including open surgery, laparoscopic surgery, and robot-assisted surgery.
POINT04
Visible even during endoscopic surgery
Microbubbles are generated at the tip of the nozzle during the mixing and spraying of the two solutions, resulting in a whitish gel that is highly visible. The sprayed area can be confirmed during surgery without the use of colorants.
Only Terumo offers a spray-type adhesion barrier, providing simpler, more reliable application to complex sites regardless of surgical approach.
Our Care
Naotaka Chino
Joined Terumo in 2006.
Joined AdSpray’s development team and led it as a development manager, involved from the feasibility stage until launch. Since then, he has been in charge of creating new themes and new developments in the digital field.
